Amyloid (amyloid) is a homogeneous, eosinophilic (eosinophilic), insoluble fibrin (fibrous protein) polymer with a common β-crossover-folding layer (βsheet) with structural characteristics that are deposited outside the cell. Protein error Folding (misfolding), and abnormal self accumulation will lead to amyloidosis (amyloidosis), cytotoxic fiber deposition, resulting in tissue damage, resulting in 23 different types of amyloid syndrome, more than 400 diseases, including Attsham disease, Parkinson syndrome, Type II diabetes mellitus, cataract, prion diseases and so on.
Amyloid plaque (amyloid plaque) and nerve fiber tangles (neurofibrillary Tangles;nft) are pathological features of amyloid syndrome. Sulfur t (Thioflavine t), cationic benzene and thiazole (benzothiazole) derivative, with the participation of hydrochloric acid, is the most commonly used amyloid fluorescence probe, which is formed by the methylation of dehydrogenation of aniline (Dehydrothiotoluidine). Identification and quantitative analysis of fibrosis kinetics in vivo or in vitro.
Sulfur-thioflavine is more stable and broad-spectrum than sulfur-s (s), which is better in vivo detection and is especially suitable for testing in liquid condition. Once the starch-like protein fiber (Oligomer) was combined, its fluorescence intensity (excitation wavelength 440nm, emitting wavelength 490nm) was significantly enhanced, showing apple green fluorescence.
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